Prooxidant action of aluminum ion - Stimulation of iron-mediated lipid peroxidation by aluminum

Prooxidant nature of aluminum ion was analyzed in relation to iron coordina tion. Aluminum ion effectively enhanced the formation of thiobarbituric aci d-reactive substances as a marker of lipid peroxidation of microsomes from rat liver under the acidic conditions, and this metal further attenuated th e antioxidant action of flavonoids such as quercetin and baicalein under ne utral conditions. Autooxidation of ferrous ion was markedly inhibited by al uminum ion. Aluminum can act as a prooxidant by stabilizing reduced iron th e initiating species for lipid peroxidation, and by inhibiting the antioxid ant action of flavonoid.