J. Bengzon et al., Regulation of norepinephrine transporter and tyrosine hydroxylase mRNAs after kainic acid-induced seizures, BRAIN RES, 842(1), 1999, pp. 239-242
Noradrenergic locus coeruleus (LC) efferents to the forebrain suppress seiz
ures in several models of epilepsy. Using in situ hybridization, we demonst
rate that tyrosine hydroxylase (TH) and norepinephrine transporter (NET) bu
t not vesicular monoamine transporter 2 (VMAT2) mRNA levels an transiently
elevated in LC neurons following kainic acid-induced status epilepticus. Th
ese increases of TH and NET mRNAs and presumably of the proteins themselves
might enhance synthesis and reuptake of NE postictally. (C) 1999 Published
by Elsevier Science B.V. All rights reserved.