Benign familial Degos disease worsening during immunosuppression

We describe a 61-year-old woman with skin lesions consistent with those fou nd in Degos disease, both in clinical and in histological appearance. She h ad had several of these lesions for many years, as had her mother, sister a nd niece, In 1991, she underwent cadaveric renal transplantation and was tr eated with immunosuppression: prednisolone, azathioprine and cyclosporin. A t that time, she developed many more characteristic skin lesions, and these were slightly larger and more noticeable than those she had had previously , She and the other affected family members appear to fit into the more ben ign subgroup of Degos disease, and it seems that her immunosuppression aggr avated her cutaneous disease.