IN-VITRO AND IN-VIVO SCREENING OF ORGANOSILICON(IV) AND ORGANOTIN(IV)COMPLEXES OF SALICYLANILIDE AND ITS DERIVATIVES

Stereochemical and biochemical aspects of some organosilicon(IV) and o rganotin(IV) complexes of salicylanilide (SalOH) and its thiosemicarba zone (HOSal.TSCZH) have been described. On the basis of spectral studi es pentacoordinated and hexacoordinated states for silicon and tin hav e been established. In order to assess their growth inhibitory potency , salicylanilide, its thiosemicarbazone and their organo complexes hav e been tested in vitro against a number of pathogenic fungi and bacter ia at different concentrations and were found to possess remarkable fu ngicidal and bactericidal properties. The testicular sperm density, te sticular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trails and biochemical parameters of reproductive organs have been examined and discussed.