The PIK-related kinases intercept conventional signaling pathways

Authors
Kuruvilla, FG Schreiber, SL
Citation
Fg. Kuruvilla et Sl. Schreiber, The PIK-related kinases intercept conventional signaling pathways, CHEM BIOL, 6(5), 1999, pp. R129-R136
Citations number
70
Categorie Soggetti
Biochemistry & Biophysics
Journal title
CHEMISTRY & BIOLOGY
ISSN journal
10745521 → ACNP
Volume
6
Issue
5
Year of publication
1999
Pages
R129 - R136
Database
ISI
SICI code
1074-5521(199905)6:5<R129:TPKICS>2.0.ZU;2-C
Abstract
Early efforts to place the first cloned mammalian PIK-related kinase, FRAP, into a conventional membrane to nuclear pathway met with little success. M ore recent data suggest that members of the family of PIK-related kinases a ct as intracellular sensors that govern radial. and horizontal pathways. Th ese pathways can impinge upon classical membrane to nuclear pathways, as we ll as components of the cell cycle machinery.