Kf. Hilgers et al., 1166 A/C polymorphism of the angiotensin II type 1 receptor gene and the response to short-term infusion of angiotensin II, CIRCULATION, 100(13), 1999, pp. 1394-1399
Citations number
34
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Background-Previous studies reported an association of the 1166 A/C polymor
phism of the angiotensin II (Ang II) type 1 receptor gene with high blood p
ressure and cardiovascular disease. We tested the hypothesis that this poly
morphism affects the blood-pressure, renal hemodynamic, and aldosterone res
ponse to infused Ang II.
Methods and Results-Young, male, white volunteers (n = 116) with normal (n
= 65) or mildly elevated (n = 51) blood pressure on a high salt intake were
genotyped for the 1166 A/C polymorphism. Two doses of Ang II (0.5 and 3 ng
.kg(-1).min(-1) over 30 minutes each) increased blood pressure, plasma aldo
sterone, glomerular filtration rate, and filtration fraction and decreased
renal blood flow. The blood-pressure, renal hemodynamic, and aldosterone re
sponses were not significantly different between subjects homozygous for th
e A allele (n = 56) and heterozygous subjects (n = 47) or subjects homozygo
us for the C allele (n = 13). Comparison of A allele homozygotes with all C
allele carriers pooled (n = 60) or restriction of the analysis to normoten
sive volunteers also revealed no significant differences between genotypes.
Conclusions-The 1166 C variant of the Ang II type I receptor does not lead
to a greater blood-pressure, aldosterone, or renal vascular response to inf
used Ang II in young, male, white subjects. We conclude that the 1166 A/C p
olymorphism does not have a major effect on these actions of Ang II.