AUTOMATIC CORRECTION OF THE INTERFERING EFFECT OF UNSUPPRESSED INTERSPERSED REPETITIVE SEQUENCES IN COMPARATIVE GENOMIC HYBRIDIZATION ANALYSIS

Comparative genomic hybridization (CGH) is a relatively new technique whose application is increasing. The method has mostly been employed f or detection of chromosome aberrations in cancers, and a large amount of data in this field is accumulating. At the same time, efforts are m ade to improve the technique in order to increase the sensitivity and the generation of reliable results. Based on experimental data, we hav e developed a computer algorithm for eliminating some of the interferi ng effects of unsuppressed repetitive sequences in CGH analysis, and t hereby improved our CGH analysis system. (C) 1997 Wiley-Liss, Inc.