SATURATED HETEROCYCLES .252. SYNTHESIS AND STEREOCHEMISTRY OF STEREOISOMERIC 6-METHYL-SUBSTITUTED PYRIMIDO[6,1-ALPHA]ISOQUINOLINES

Authors
FULOP F TARI J BERNATH G SOHAR P DANCSO A ARGAY G KALMAN A
Citation
F. Fulop et al., SATURATED HETEROCYCLES .252. SYNTHESIS AND STEREOCHEMISTRY OF STEREOISOMERIC 6-METHYL-SUBSTITUTED PYRIMIDO[6,1-ALPHA]ISOQUINOLINES, Liebigs Annalen, (6), 1997, pp. 1165-1171
Citations number
37
Categorie Soggetti
Chemistry
Journal title
Liebigs Annalen → ACNP
ISSN journal
09473440
Issue
6
Year of publication
1997
Pages
1165 - 1171
Database
ISI
SICI code
0947-3440(1997):6<1165:SH.SAS>2.0.ZU;2-2
Abstract
Stereoisomeric (1R,3R*)- and methyl-1,2,3,4-tetrahydroisoquinoline-1- acetamides 5-8 react with formaldehyde or benzaldehyde to furnish ster eoisomeric pyrimido[6,1-a]isoquinolin-2-ones 9-18. the relative config urations and the predominant conformations of the products have been d etermined by NMR spectroscopy, and for ,6,7,11b-hexahydropyrimido[6,1- a]isoquinolin-2-one (11) by X-ray diffraction.