Diet and infectious/parasitic agents are the most common causes of large bo
wel diarrhea in dogs. A diagnosis of lymphocytic-plasmacytic colitis (the m
ost common form of colonic inflammatory bowel disease) should be reserved f
or patients in which an etiologic agent or dietary cause cannot be found. T
he cause of constipation should be established and aggressively corrected o
r controlled to prevent progression to megacolon. This article discusses th
e basics of colonic physiology, reviews the diseases most commonly associat
ed with colonic disease in dogs, and presents an approach to the management
of these disorders.