COMPARISON OF THE EEG EFFECTS OF MIDAZOLAM, THIOPENTAL, AND PROPOFOL - THE ROLE OF UNDERLYING OSCILLATORY SYSTEMS

The EEG effects of 3 intravenous sedative drugs from different chemica l families were studied during conscious sedation in 47 normal volunte ers. The drugs studied were midazolam (a benzodiazepine), propofol (an alkylphenol) and thiopental (a barbiturate). Though these drugs cause different degrees of amnesia, they have the common EEG effects of sup pressing a-rhythm and increasing total beta-power. A large portion of the increase in beta-power can be accounted for by beta-rhythms. We us ed the UNIFAC-EEG technique to differentiate oscillatory systems under lying the rhythms induced by these drugs in a quantitative fashion. Wh ile thiopental induced beta-rhythms which were similar to those appear ing during drowsiness, midazolam and propofol induced beta-rhythms wit h substantially different characteristics. The differences between the beta-rhythms induced by drug infusion and previously described 'sleep spindles' are discussed. We conclude that a quantitative analysis of beta-rhythms can differentiate the effects of these drugs on the EEG.