Adenovirus vectors for gene delivery

Recent endeavors in the development of adenovirus as a gene vector have foc used on the modification of virus tropism, the accommodation of larger gene s, and the increase in si:ability and control of transgene expression. Wher eas partial or total deletions of viral genes increase the cloning capacity and partly reduce the cellular immune response, control of the humoral res ponse, which often precludes efficient readministration, remains a challeng e.