Engineering the mouse genome by site-specific recombination

Authors
Metzger, D Feil, R
Citation
D. Metzger et R. Feil, Engineering the mouse genome by site-specific recombination, CURR OPIN B, 10(5), 1999, pp. 470-476
Citations number
78
Categorie Soggetti
Microbiology
Journal title
CURRENT OPINION IN BIOTECHNOLOGY
ISSN journal
09581669 → ACNP
Volume
10
Issue
5
Year of publication
1999
Pages
470 - 476
Database
ISI
SICI code
0958-1669(199910)10:5<470:ETMGBS>2.0.ZU;2-G
Abstract
Site-specific recombination systems are powerful tools for introducing pred etermined modifications into eukaryotic genomes. Recent advances allow the manipulation of chromosomal DNA in a spatially and temporally controlled ma nner in mice, offering unprecedented possibilities for studying mammalian g enome function and for generating animal models for human diseases.