Tolerance to vascularized organ allografts in large-animal models

Although studies of tolerance induction in large animals remain limited com pared with murine studies, a number of encouraging observations have been r ecently reported - especially in nonhuman primate models. The development o f antibodies or proteins binding to costimulatory molecules and of an immun otoxin that is active on T cells have been particularly important advances leading to expanded opportunities for extending strategies for tolerance in duction to large animals.