Non-transplant uses of mycophenolate mofetil

The immunosuppressive drug mycophenolate mofetil is a potential new treatme nt for autoimmune renal disease. In addition to its effects in modulating t he autoimmune response, mycophenolate mofetil reduces adhesion molecule exp ression and delays the progression of renal failure. Data from experimental models of glomerulonephritis, especially of lupus nephritis, have demonstr ated that mycophenolate mofetil reverses both inflammatory and autoimmune a spects of disease and influences outcome. As yet, clinical experience with mycophenolate mofetil remains anecdotal but provides a strong platform for the scientific evaluation of mycophenolate mofetil as a new therapeutic age nt for these conditions in the future. Curl Opin Nephrol Hypertens 8:563-56 7. (C) 1999 Lippincott Williams & Wilkins.