FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4

Authors
Xie, MH Holcomb, I Deuel, B Dowd, P Huang, A Vagts, A Foster, J Liang, J Brush, J Gu, QM Hillan, K Goddard, A Gurney, AL
Citation
Mh. Xie et al., FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4, CYTOKINE, 11(10), 1999, pp. 729-735
Citations number
40
Categorie Soggetti
Cell & Developmental Biology
Journal title
CYTOKINE
ISSN journal
10434666 → ACNP
Volume
11
Issue
10
Year of publication
1999
Pages
729 - 735
Database
ISI
SICI code
1043-4666(199910)11:10<729:FANFGF>2.0.ZU;2-6
Abstract
We have identified a novel fibroblast growth factor, FGF-19, the most dista nt member of the FGF family described to date. FGF-19 is a high affinity, h eparin dependent ligand for FGFR4 and is the first member of the FGF family to show exclusive binding to FGFR4. Human FGF-19 maps to chromosome 11 q13 .1, a region associated with an osteoporosis-pseudoglioma syndrome of skele tal and retinal defects. FGF-19 message is expressed in several tissues inc luding fetal cartilage, skin, and retina, as well as adult gall bladder and is overexpressed in a colon adenocarcinoma cell line. (C) 1999 Academic Pr ess.