B. Jorgensen et al., Luminal loss and restenosis after coronary angioplasty - The role of lipoproteins and lipids, EUR HEART J, 20(19), 1999, pp. 1407-1414
Aims Lipoproteins and lipids, especially lipoprotein(a), have been studied
as risk factors for restenosis after coronary angioplasty with conflicting
results. We investigated the association between serum levels of lipoprotei
n(a) apolipoprotein A-1, apolipoprotein B-100, total-cholesterol, high dens
ity lipoprotein-cholesterol, triglycerides, and coronary luminal loss and r
estenosis after angioplasty.
Methods The lipoproteins and lipids were measured in 305 consecutive patien
ts who underwent successful angioplasty and reangiography 20 +/- 3 weeks af
ter angioplasty. Single-vessel dilatation was performed in 251 patients. Lu
minal loss was defined as minimal luminal diameter postangioplasty minus mi
nimal luminal diameter at follow-up, divided by the interpolated reference
diameter of the vessel. Restenosis was defined according to three dichotomo
us categorical criteria: (1) >50% diameter stenosis at follow-up (2) loss o
f >50% of the gain achieved by angioplasty, (3) the need for target vessel
revascularization.
Results There was no significant association between the serum levels of li
poproteins and lipids and luminal loss. Univariate analysis did not show an
y significant difference in the serum levels of any of the lipoproteins and
lipids between the restenosis and no-restenosis groups. Multivariate analy
sis revealed that only the angiographic variables (luminal gain and post-an
gioplasty minimal luminal diameter) were associated with luminal loss and r
estenosis after angioplasty.
Conclusion Lipoproteins and lipids were neither associated with luminal los
s nor independent risk factors for restenosis after angioplasty.