Eccrine porocarcinoma, tricholemmal carcinoma and multiple squamous cell carcinomas in a single patient

A 75-year old woman without remarkable medical history presented with a lar ge eccrine porocarcinoma of the trabelucar type located on her leg. This tu mor was associated with two invasive squamous cell carcinomas of the legs, two Bowen's diseases of her thigh and arm and multiple actinic keratoses of the face. Despite major surgery, local recurrence of the porocarcinoma was observed 6 months later. During the 3-year follow-up after a second surgic al intervention, this lesion did not reccur, but the patient developed a ra pidly enlarging ulcerated tumor of the forehead which proved to be trichole mmal carcinoma. Although no carcinogenetic factor or familial history of mu ltiple neoplasms could be evidenced, the occurrence of multiple tumors of v arious histogenesis over a 1 year period of time is unlikely to be fortuito us. Such an association of rare adnexal neoplasms has not yet been describe d.