Bwj. Mol et al., Are gestational age and endometrial thickness alternatives for serum humanchorionic gonadotropin as criteria for the diagnosis of ectopic pregnancy?, FERT STERIL, 72(4), 1999, pp. 643-645
Objective: To compare gestational age and endometrial stripe thickness meas
urement with serum hCG measurement as criteria for the diagnosis of ectopic
pregnancy (EP).
Design: Prospective study.
Setting: Two large teaching hospitals in Amsterdam, the Netherlands.
Patient(s): Three hundred fifty-four consecutively seen pregnant patients w
ho presented between September 1993 and April 1996 with suspected EP and in
whom transvaginal ultrasonogram showed no intrauterine pregnancy or EP. Ul
trasonography was performed by one of the study investigators or, during sh
ifts, by the resident on call.
Intervention(s): None.
Main Outcome Measure(s): The accuracy of gestational age, endometrial strip
e thickness, and serum hCG measurement in the diagnosis of EP was evaluated
with receiver operating characteristic curve analysis.
Result(s): Gestational age and endometrial stripe thickness could not discr
iminate between patients with EP and patients without EP, whereas serum hCG
had an acceptable area under the receiver operating characteristic curve.
Conclusion(s): Gestational age and endometrial thickness are not useful in
the diagnosis of EP. Serum hCG measurement is the diagnostic instrument of
choice in patients with suspected EP when transvaginal ultrasonography does
not reveal a diagnosis. (Fertil Steril(R) 1999,72:643-5. (C) 1999 by Ameri
can Society for Biostatistics, Academic Reproductive Medicine.).