Perifollicular blood flow Doppler indices, but not follicular pO(2), pCO(2), or pH, predict oocyte developmental competence in in vitro fertilization

Citation
S. Huey et al., Perifollicular blood flow Doppler indices, but not follicular pO(2), pCO(2), or pH, predict oocyte developmental competence in in vitro fertilization, FERT STERIL, 72(4), 1999, pp. 707-712
Citations number
23
Categorie Soggetti
Reproductive Medicine","da verificare
Journal title
FERTILITY AND STERILITY
ISSN journal
00150282 → ACNP
Volume
72
Issue
4
Year of publication
1999
Pages
707 - 712
Database
ISI
SICI code
0015-0282(199910)72:4<707:PBFDIB>2.0.ZU;2-B
Abstract
Objective: To assess the relationships among perifollicular blood how; foll icular fluid pO(2), pCO(2), and pH; oocyte developmental capacity; preimpla ntation embryo quality. Design: Prospective study. Setting: Academic, tertiary care institution. Patient(s): Unselected, gonadotropin-stimulated IVF cycles. Intervention(s): Color, pulsed Doppler analysis of perifollicular blood flo w, and follicular pO(2), pCO(2), and pH determinations of randomly designat ed, mapped ovarian follicles. Main Outcome Measure(s): Fertilization and day 3 embryo cleavage and morpho logy. Result(s): Perifollicular vascularity indices were significantly and negati vely correlated with day 3 embryo cleavage. Pulsatility index and S-D ratio also were significantly and negatively correlated with follicular pO(2). T he same correlation was found between resistance index and the fertilizatio n rate of preovulatory oocytes. No relationship existed between follicular metabolic analysis and fertilization or embryo quality. The resistance inde x had a sensitivity of 0.57 and a specificity of 0.71 for the prediction of advanced embryo cleavage status. Conclusion(s): Results confirm and extend previous reports demonstrating th at color, pulsed Doppler ultrasound analysis of individual preovulatory fol licles during IVF therapy may provide an indirect index of the developmenta l competence of the corresponding oocyte. Although these methods may provid e means to select embryos for transfer with the highest implantation potent ial, the moderate predictive power showed so far may limit their clinical a pplicability. (Fertil Steril(R) 1999;72.707-12. (C) 1999 by American Societ y for Reproductive Medicine.).