Stereological estimates of nuclear star volume and vessels as predictors of chemotherapy response in small cell carcinoma of the lung: a preliminary report
C. Caporrino et al., Stereological estimates of nuclear star volume and vessels as predictors of chemotherapy response in small cell carcinoma of the lung: a preliminary report, HISTOPATHOL, 35(3), 1999, pp. 257-266
Citations number
42
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research Diagnosis & Treatment
Aims: This study was designed to evaluate the role of morphometric and clin
ical parameters in predicting chemotherapy responder patients with small ce
ll carcinoma of the lung.
Methods and results: Morphometric studies were performed by means of point
counting techniques. Forty-six patients were included in this study. Group
1 patients (n = 19) were these without response to chemotherapy; Group 2 (n
= 27) was composed by patients with partial or complete response to chemot
herapy. Logistic regression analysis was used to attain the best separation
of non-responder from responder patients, Star volume of the nuclei and ve
ssel were selected during the backward procedure as relevant variables to c
haracterize the two groups of patients. The overall sensitivity of the mode
l was 80.43%.
Conclusions: Our results indicate that histopathological data may help to p
redict the chemotherapy response in patients with small cell lung carcinoma
, and encourage the use of morphometric procedures in histopathological ana
lysis of this type of lung tumours.