Collagenous spherulosis mimicking keratinizing squamous metaplasia in a borderline endometrioid tumour of the ovary

Aims: Collagenous spherulosis (CS) is a rare lesion which is an incidental finding in breast and salivary glands. It is characterized by fibrillar sph erules exhibiting an intrinsic radiating or concentric pattern which are su rrounded by myoepithelial cells. This entity can be misdiagnosed as adenoid cystic carcinoma and in-situ ductal carcinoma, Methods and results: We report here the first case of CS arising in a borde rline endometrioid tumour of the ovary where it merged with squamous metapl asia, Conclusion: This observation illustrates another pitfall of CS which can be misidentified as keratin pearls. The pathogenesis remains unclear but it h as been claimed that the accumulation of basement membrane material may be due to the proliferation of pre-existing myoepithelial cells that secrete m atrix components, Since ovarian tumours do not contain myoepithelial cells, one should assume that the epithelial cells differentiate towards myoepith elial cells as it has been shown in vitro and ex vivo.