Alpha-toxin damages the air-blood barrier of the lung in a rat model of Staphylococcus aureus-induced pneumonia

Authors
McElroy, MC Harty, HR Hosford, GE Boylan, GM Pittet, JF Foster, TJ
Citation
Mc. Mcelroy et al., Alpha-toxin damages the air-blood barrier of the lung in a rat model of Staphylococcus aureus-induced pneumonia, INFEC IMMUN, 67(10), 1999, pp. 5541-5544
Citations number
19
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
67
Issue
10
Year of publication
1999
Pages
5541 - 5544
Database
ISI
SICI code
0019-9567(199910)67:10<5541:ADTABO>2.0.ZU;2-X
Abstract
We have shown that injury to alveolar epithelial type I cells may account, in part, for damage to the air-blood barrier of the lung in a rat model of Staphylococcus aureus pneumonia. We have also shown that alpha-toxin is an important cause of damage to the air-blood barrier; however, our data sugge st that the toxin is not acting directly on alveolar type I cells.