Tumor necrosis factor (TNF) and a TNF-mimetic peptide modulate the granulomatous response to Mycobacterium bovis BCG infection in vivo

Authors
Roach, DR Briscoe, H Baumgart, K Rathjen, DA Britton, WJ
Citation
Dr. Roach et al., Tumor necrosis factor (TNF) and a TNF-mimetic peptide modulate the granulomatous response to Mycobacterium bovis BCG infection in vivo, INFEC IMMUN, 67(10), 1999, pp. 5473-5476
Citations number
21
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
67
Issue
10
Year of publication
1999
Pages
5473 - 5476
Database
ISI
SICI code
0019-9567(199910)67:10<5473:TNF(AA>2.0.ZU;2-R
Abstract
Tumor necrosis factor (TNF) is a critical mediator in the immune response t o mycobacteria, particularly in the formation and maintenance of granulomas . Treatment of Mycobacterium bovis BCG-infected mice with TNF and a TNF-mim etic peptide (TNF70-80) altered the number and cellular composition of gran ulomas. This change was associated with a moderate decrease in the bacteria l burden.