Hysteroscopic evaluation of the endometrium of post-menopausal patients with breast cancer before and after tamoxifen use

Objective: To evaluate by hysteroscopy and histopathology the influence of tamoxifen in the endometrium df post-menopausal women with previous breast cancer. Method: Out of 46 patients studied, 20 of them had been using tamox ifen for an average length of 12 months, and are still being followed-up. H ysteroscopy with endometrial biopsy was performed before and after the use of the drug. Results: The prevalence of endometrial activity before and aft er this hormoniotherapy was the same, i.e. 10.0%, showing a non-significant variation. Conclusion: The hormoniotherapy with tamoxifen has not increase d the endometrial proliferactive activity of postmenopausal patients with b reast cancer. The most common hysteroscopical finding was numerous vesicles disseminated throughout the uterine cavity probably due to atrophy of the endometrium, (C) 1999 International Federation of Gynecology and Obstetrics .