THE INFLUENCE OF PRESSURE AND TEMPERATURE ON THE KINETICS OF VACUUM DRYING OF KETOPROFEN

This paper explores the influence of temperature and pressure on dryin g kinetics of 2-(3-benzoylphenil propionic acid) - ketoprofen, in a va cuum dryer on laboratory scale. Experimentally determined relations be tween moisture content and drying rate vs time, were approximated with an exponential model. Model parameters were correlated with drying co nditions (temperature, pressure) and defined by functions of their pot entions. From an energy balance of the process, a mathematical model f or simulating dependence of sample temperature vs drying time, and moi sture content of material, has been developed. Simulation of the dryin g kinectics and sample temperature, by use of those functional depende ncies shows good agreement with experimental results.