Humankind is on a similar evolutionary process to animals. Biological react
ions in the human heart will be reviewed, and consideration will be made ab
out what can be done in cardiology, from the viewpoints of basic, clinical
and community medicine. Functional reactions of the heart to acute loading
(exercise, etc) comprise myocardial contractility, preload, pump function a
nd peripheral factors, and are mobilized step by step in that order, to mai
ntain normal functioning. Morphological reactions to chronic loading (hyper
tension etc) comprise hypertrophy and dilatation, which are caused by mecha
nical and nonmechanical factors, but may not always be mobilized to maintai
n normal functioning. Various neurohumoral factors take part in the mechani
sms, and modifications, of these reactions. They act in a complex manner ac
cording to the biological conditions, and may not always act to maintain no
rmal functioning. The biological reactions in the heart (ie, Basic Cardiolo
gy) should not be interpreted as having purpose; that is, putting a value o
n humankind, although medical treatment (Clinical Cardiology) and the solut
ion of health problems in the community (Community Cardiology) should be do
ne from this viewpoint.