This paper describes a quantitative study conducted on an intensive care un
it in the north of England. It involved the collection of data from the exi
sting records of 65 patients consecutively sampled from a predetermined dat
e provided that they stayed more than 24 hours and had an arterial line in
situ. As patient records were used, ethical approval was not necessary. The
objectives of the study were to quantify the mean number of blood gas samp
les taken per patient and estimate the mean blood loss resulting from this,
including discard volume. Limitations include reliance on records and lack
of an economic evaluation. The results show that blood loss in this study
was greater than that reported elsewhere. Patients who were ventilated for
24 hours or more had a statistically significant greater blood loss when co
mpared to those who were not (P < 0.001). A subgroup of patients undergoing
renal replacement therapy had the greatest blood loss (mean 55.18 ml per d
ay). This loss was statistically significant when compared to patients not
in acute renal failure (P = 0.007). When patients undergoing multiple thera
pies normally associated with increased sampling were compared to patients
not receiving such therapies, there was no statistically significant differ
ence in blood loss. The need to change current nursing practice to reduce i
atrogenic anaemia is emphasized.