Decatromicins A and B, new antibiotics produced by Actinomadura sp MK73-NF4 - II. Structure determination

Authors
Momose, I Hirosawa, S Nakamura, H Naganawa, H Iinuma, H Ikeda, D Takeuchi, T
Citation
I. Momose et al., Decatromicins A and B, new antibiotics produced by Actinomadura sp MK73-NF4 - II. Structure determination, J ANTIBIOT, 52(9), 1999, pp. 787-796
Citations number
14
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF ANTIBIOTICS
ISSN journal
00218820 → ACNP
Volume
52
Issue
9
Year of publication
1999
Pages
787 - 796
Database
ISI
SICI code
0021-8820(199909)52:9<787:DAABNA>2.0.ZU;2-O
Abstract
The structures of decatromicins A and B that strongly inhibit the growth of MRSA were elucidated by the analysis of various NMR experiments. The plana r structure was determined by H-1, C-13, COSY, HMQC and HMBC NMR spectra. T he relative configuration of aglycone was elucidated by NOESY experiments a nd the absolute structure was determined by application of the modified Mos her's method. The absolute structure of glycosyl moiety was determined by X -ray analysis of the O-(p-bromobenzoyl) derivative.