Bringing new medicines to the market depends on the rapid discovery of new
and effective drugs, often initiated through the biological testing of many
thousands of compounds in high-throughput screening (HTS). Mixing compound
s together into pools for screening is one way to accelerate this process a
nd reduce costs. This paper contains both theoretical and experimental data
which suggest that careful selection of compounds to be pooled together is
necessary in order to reduce the risk of reactivity between compounds with
in the pools.