State-of-the-art in liquid chromatography-mass spectrometry

Impressive progress has been made in the technology and application of comb ined liquid chromatography-mass spectrometry (LC-MS) in the past decennium. From a technique, that could only be used by a specialist, it has develope d into a routinely applicable technique. LC-MS has become the method-of-cho ice of analytical support in many stages of drug development within pharmac eutical industries and has found its way into environmental, biochemical an d other laboratories. This paper provides a perspective on the current tech nology, principles and applications of LC-MS. (C) 1999 Elsevier Science B.V . All rights reserved.