Coenzyme Q(10) and its role in heart disease

Coenzyme Q(10) (CoQ(10)) deficiency has been observed in apparently healthy subjects as well as in patients with congestive heart failure, angina pect oris, coronary artery disease, cardiomyopathy, hypertension, mitral valve p rolapse and after coronary revascularization. CoQ(10) bolsters the synthesi s of ATP and inhibits free radical damage, hence is useful in preventing ce llular damage during ischaemia-reperfusion injury. The clinical benefits ar e mainly due to its ability to improve energy production, antioxidant activ ity, and membrane stabilizing properties. Several small scale studies indic ate that coenzyme Q could be useful in patients with congestive heart failu re, angina pectoris, cardiomyopathy, coronary artery disease, acute myocard ial infarction and in the preservation of myocardium. CoQ(10) may also decr ease lipoprotein (a) and plasma insulin. CoQ(10) is normally present in the low-density lipoprotein cholesterol fraction and inhibits its oxidation in dicating that it can inhibit atherosclerosis. It can also regenerate vitami n E. CoQ(10) is known for producing minor gastrointestinal discomfort and e levation in SGOT and LDH when used.