Comparative stratum corneum tolerance to antiseptic cleansing products

Nosocomial infections remain a stubborn problem. Although the use of antise ptic body and hand wash solutions is the greatest deterrent tn such infecti ons, adherence ro strict procedures fails when irritation is perceived. Ant imicrobial efficacy may be reduced and compliance may fail secondary to irr itancy-related discomfort. Few studies have been performed to assess the ri sk of skin damage by antiseptic cleansers, and they have yielded contradict ory results. The present study was conducted using the corneosurfametry bio assay to compare three proprietary antiseptic wash formulations to water an d to a mild unmedicated skin cleansing product. Large differences in irrita ncy potential between the test products were found. The providone-iodine wa sh solution (Iso-Betadine Uniwash) induced significantly less damage to the stratum corneum than the chlorhexidine (Hibiscrub) and quaternary ammonium (RBS HDS 10) products. In conclusion, as well as the in vitro potency and spectrum of activity of antiseptic wash solutions, it is important to bear in mind the potential damage they can inflict on the stratum corneum.