Biocompatibility of an adhesive system applied to exposed human dental pulp

Human pulp tissue was directly capped with All Bond 2, or calcium hydroxide and evaluated 7, 30, or 60 days after the procedures, Histological analysi s was performed to assess the inflammatory cell response, tissue disorganiz ation, dentin bridging, and the presence of bacteria. At 7 days, with All B ond 2 capping, there was a large area of neutrophilic infiltrate underlying the pulp capping material, and the death of adjacent odontoblasts, was obs erved. However, with time, the neutrophilic reaction was replaced by fibrob lastic proliferation with macrophages and giant cells surrounding globules of resin scattered in the coronal pulp tissue. The persistent inflammatory reaction and hyaline alteration of extracellular matrix inhibited complete pulp repair or dentin bridging. In contrast, at 7 days, the pulp tissue cap ped with calcium hydroxide exhibited odontoblast-like cells organized under neath coagulation necrosis. Pulp repair evolved into apparent complete dent in bridge formation at 60 days. All Bond 2 did not appear to allow any pulp repair and does not appear to be indicated for direct pulp capping of huma n teeth.