Human pulp tissue was directly capped with All Bond 2, or calcium hydroxide
and evaluated 7, 30, or 60 days after the procedures, Histological analysi
s was performed to assess the inflammatory cell response, tissue disorganiz
ation, dentin bridging, and the presence of bacteria. At 7 days, with All B
ond 2 capping, there was a large area of neutrophilic infiltrate underlying
the pulp capping material, and the death of adjacent odontoblasts, was obs
erved. However, with time, the neutrophilic reaction was replaced by fibrob
lastic proliferation with macrophages and giant cells surrounding globules
of resin scattered in the coronal pulp tissue. The persistent inflammatory
reaction and hyaline alteration of extracellular matrix inhibited complete
pulp repair or dentin bridging. In contrast, at 7 days, the pulp tissue cap
ped with calcium hydroxide exhibited odontoblast-like cells organized under
neath coagulation necrosis. Pulp repair evolved into apparent complete dent
in bridge formation at 60 days. All Bond 2 did not appear to allow any pulp
repair and does not appear to be indicated for direct pulp capping of huma
n teeth.