Identification of CD18 as a novel Taxol binding/signaling protein in murine macrophage membranes

Authors
Vogel, SN Bhat, N Carboni, JM Mayadas, TN Blanco, J Perera, PY Golenbock, DT
Citation
Sn. Vogel et al., Identification of CD18 as a novel Taxol binding/signaling protein in murine macrophage membranes, J ENDOTOX R, 5(3), 1999, pp. 170-173
Citations number
23
Categorie Soggetti
Immunology
Journal title
JOURNAL OF ENDOTOXIN RESEARCH
ISSN journal
09680519 → ACNP
Volume
5
Issue
3
Year of publication
1999
Pages
170 - 173
Database
ISI
SICI code
0968-0519(199902)5:3<170:IOCAAN>2.0.ZU;2-V
Abstract
The anti-tumor agent, Taxol, is a potent LPS mimetic in murine macrophages, an activity that is dissociable from its well-characterized anti-mitotic a ctivity which is mediated by microtubule hyperstabilization. A photoactivat able Taxol analog was used to identify components of a putative, shared LPS signaling apparatus in murine macrophage membranes. We report here that CD 18, the beta chain of the beta(2)-integrin, Mac-1, represents a major Taxol binding protein in murine macrophages.