Sn. Vogel et al., Identification of CD18 as a novel Taxol binding/signaling protein in murine macrophage membranes, J ENDOTOX R, 5(3), 1999, pp. 170-173
The anti-tumor agent, Taxol, is a potent LPS mimetic in murine macrophages,
an activity that is dissociable from its well-characterized anti-mitotic a
ctivity which is mediated by microtubule hyperstabilization. A photoactivat
able Taxol analog was used to identify components of a putative, shared LPS
signaling apparatus in murine macrophage membranes. We report here that CD
18, the beta chain of the beta(2)-integrin, Mac-1, represents a major Taxol
binding protein in murine macrophages.