Antinociceptive and anti-inflammatory activity of Sida rhomboidea leaves

Various organic extracts of Sida rhomboidea leaves were studied for antinoc iceptive and anti-inflammatory activity at a dose of 200 mg/kg. Ethyl aceta te extract has shown significant (P < 0.01) antinociceptive activity. Perce ntage inhibition of edema by butanolic extract (33.05, P < 0.001) is compar able to that of phenylbutazone, 100 mg/kg inhibition (38.83%). Phytochemica l screening of the extracts indicated the presence of alkaloids, steroids a nd/or triterpenoids and their glycosides, tannins, flavonoids and their gly cosides, carbohydrates and absence of cardiac glycosides. (C) 1999 Publishe d by Elsevier Science Ireland Ltd. All rights reserved.