During oogenesis the oocyte is arrested in meiosis twice. First at prophase
I, then a second time at metaphase I in many invertebrates and in metaphas
e II in the vast majority of vertebrates. Meiosis resumption is triggered b
y the sperm. This article examines mechanisms that cause oocytes' at-rest i
n meiosis and how spermatozoa help the oocyte to get out of this cellular p
redicament. (C) 1999 Wiley-Liss, Inc.