Case Report: Lamivudine therapy for submassive hepatic necrosis due to reactivation of hepatitis B following chemotherapy

Authors
Maguire, CM Crawford, DHG Hourigan, LF Clouston, AD Walpole, ET Powell, EE
Citation
Cm. Maguire et al., Case Report: Lamivudine therapy for submassive hepatic necrosis due to reactivation of hepatitis B following chemotherapy, J GASTR HEP, 14(8), 1999, pp. 801-803
Citations number
7
Categorie Soggetti
Gastroenerology and Hepatology","da verificare
Journal title
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
ISSN journal
08159319 → ACNP
Volume
14
Issue
8
Year of publication
1999
Pages
801 - 803
Database
ISI
SICI code
0815-9319(199908)14:8<801:CRLTFS>2.0.ZU;2-F
Abstract
This report describes the case of a 53-year-old woman who developed severe hepatitis following chemotherapy for breast carcinoma. The patient was hepa titis B surface antigen positive, e antigen negative and e antibody positiv e and had high levels of hepatitis B virus-DNA. Liver biopsy revealed subma ssive hepatic necrosis, consistent with reactivation of hepatitis B. Treatm ent with lamivudine resulted in rapid loss of hepatitis B virus-DNA, resolu tion of hepatitis and clinical recovery. (C) 1999 Blackwell Science Asia Pt y Ltd.