G. Patriarca et al., Allergy to betalactams: Relationship between chemical structure and antigenicity of molecules, J INVES ALL, 9(4), 1999, pp. 215-221
Citations number
37
Categorie Soggetti
Clinical Immunolgy & Infectious Disease
Journal title
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY & CLINICAL IMMUNOLOGY
As betalactams (penicillins, cephalosporins, carbapenems, monobactams, beta
lactamase inhibitors) are the most widely used antibiotic drugs worldwide,
allergy to betalactams is a frequent problem encountered in clinical practi
ce, concerning from 0.7-8% of treated patients. It is now clear that the an
tigenicity of these drugs is strictly related to the chemical structure of
the various molecules and of their constituent parts. In this paper we firs
t describe the chemical structure of betalactams and then try to establish
a correlation between this structure and their antigenicity.