Antimicrobial and antitumor activities of mycosporulone

The conditions for optimal production of mycosporulone (1) are given. Its c ytotoxic, antimicrobial, and antitumor activities are described. The biolog ical activities of 1 were compared with those of known antibacterial, antif ungal, and antitumor agents. The compound was particularly active against P seudomonas aeruginosa and Staphylococcus aureus (resistant to penicillin). Compound 1 was not toxic to normal human cells (MRC5), although it exhibite d cytotoxic activity against the human tumor cell lines MDA-MB 231 and PC3 and the murine L-1210 leukemia cell line.