Tanikolide, a toxic and antifungal lactone from the marine cyanobacterium Lyngbya majuscula

A new brine-shrimp toxic and antifungal compound, tanikolide 1, has been is olated from the lipid extract of a Madagascan collection of the marine cyan obacterium Lyngbya majuscula. The structure of tanikolide was determined by spectroscopic methods, relying heavily on 2D NMR spectroscopy. The absolut e configuration at C-5 of tanikolide was established as R by oxidizing the primary alcohol to an acid and analyzing the corresponding (R)- and (S)-PGM E amide derivatives by H-1 NMR.