Ongoing protocols for non-AIDS primary central nervous system lymphoma

The optimal treatment for primary central nervous system lymphoma (PCNSL) r emains undefined. In this paper, we review the main multi-institutional ong oing protocols for PCNSL. Most of the current protocols evaluate the effica cy of combination high-dose methotrexate-based chemotherapy and brain irrad iation in phase II studies. Some trials focus on chemotherapy alone as init ial treatment, in order to minimize long-term cognitive sequellae. Because old age appears as a major predisposing factor for combined RT and CT neuro toxicity some specific protocols have been proposed to this particular popu lation.