ROLE OF FIBROBLAST GROWTH-FACTORS IN NEURAL TRAUMA

Following a traumatic insult to the adult mammalian central nervous sy stem (CNS), a complex of molecular and cellular responses ensues. Seve ral peptide growth factors seem implicated in the CNS traumatic respon se. Furthermore, several of them, like some of the members of the fibr oblast growth factor family of polypeptides seem to have a protective role. The purpose of this article is to point toward some basic aspect s of FGFs neuroprotective activity against traumatic CNS injuries for the development of novel therapeutic strategies in neural trauma.