The syndrome of the trephined has been described in many patients with
cranial defects as an indication for cranioplasty. Cerebral blood Now
changes, the effect of the atmospheric pressure on the brain, as well
as cerebrospinal fluid hydrodynamic changes have been postulated as t
he possible reasons for this syndrome. Using dynamic phase-contrast ma
gnetic resonance imaging we measured arterial, venous, and cerebrospin
al fluid Now into and out oi the skull, before and after cranioplasty
in one patient whose bone nap was removed because of osteomyelitis. We
report significant changes in the oscillatory CSF Now after craniopla
sty. A moderate increase in venous outflow as well as a two-fold incre
ase in craniocaudal cerebrospinal fluid systolic Now velocity was meas
ured after the skull closure. The changes in the cerebrospinal fluid o
scillatory Now at the level of the craniovertebral junction could refl
ect changes in the compliance of the craniospinal system produced by c
losure of the cranial defect.