ON THE FORMATION OF LONGMERS IN PHOSPHOROTHIOATE OLIGODEOXYRIBONUCLEOTIDE SYNTHESIS

Authors
KROTZ AH KLOPCHIN PG WALKER KL SRIVATSA GS COLE DL RAVIKUMAR VT
Citation
Ah. Krotz et al., ON THE FORMATION OF LONGMERS IN PHOSPHOROTHIOATE OLIGODEOXYRIBONUCLEOTIDE SYNTHESIS, Tetrahedron letters, 38(22), 1997, pp. 3875-3878
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
22
Year of publication
1997
Pages
3875 - 3878
Database
ISI
SICI code
0040-4039(1997)38:22<3875:OTFOLI>2.0.ZU;2-0
Abstract
The extent of longmer formation in phosphorothioate oligodeoxyribonucl eotide synthesis through amidite chemistry on solid support depends on base composition, contact time and acidity of the promotor used for a ctivation of the phosphoramidite, A longmer formation mechanism that i nvolves dedimethoxytritylation of the phosphite triester intermediate is proposed. (C) 1997 Elsevier Science Ltd.