THE HIGHLY DIASTEREOSELECTIVE PALLADIUM-CATALYZED CYCLIZATIONS - STEREOSELECTIVE SYNTHESES OF CIS AND TRANS-DISUBSTITUTED HYDROXYCYCLOPENTANES

Authors
SUH YG JUNG JK KIM SA SHIN DY MIN KH
Citation
Yg. Suh et al., THE HIGHLY DIASTEREOSELECTIVE PALLADIUM-CATALYZED CYCLIZATIONS - STEREOSELECTIVE SYNTHESES OF CIS AND TRANS-DISUBSTITUTED HYDROXYCYCLOPENTANES, Tetrahedron letters, 38(22), 1997, pp. 3911-3914
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
22
Year of publication
1997
Pages
3911 - 3914
Database
ISI
SICI code
0040-4039(1997)38:22<3911:THDPC->2.0.ZU;2-6
Abstract
A new variant of palladium-catalyzed stereoselective cyclization has b een developed. This process provides an excellent 1,2-diastereocontrol of two new stereogenic centers as well as 1,3-asymmetric induction. I n addition, desulfonylation of the cyclization product with retention of the initial stereochemistry and conversion of the desulfonylation p roduct to the advanced carbaprostacyclin intermediate is described. (C ) 1997 Elsevier Science Ltd.