A NOVEL SOLID SUPPORT FOR SYNTHESIS OF 3'-PHOSPHORYLATED CHIMERIC OLIGONUCLEOTIDES CONTAINING INTERNUCLEOSIDIC METHYL PHOSPHOTRIESTER AND METHYLPHOSPHONATE LINKAGES

Authors
GUZAEV A LONNBERG H
Citation
A. Guzaev et H. Lonnberg, A NOVEL SOLID SUPPORT FOR SYNTHESIS OF 3'-PHOSPHORYLATED CHIMERIC OLIGONUCLEOTIDES CONTAINING INTERNUCLEOSIDIC METHYL PHOSPHOTRIESTER AND METHYLPHOSPHONATE LINKAGES, Tetrahedron letters, 38(22), 1997, pp. 3989-3992
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
22
Year of publication
1997
Pages
3989 - 3992
Database
ISI
SICI code
0040-4039(1997)38:22<3989:ANSSFS>2.0.ZU;2-C
Abstract
A novel solid phase synthesis of 3'-phosphorylated oligonucleotides is described. The chain assembly is carried out by phosphoramidite strat egy on solid support 2, which allows a mild and fast release of the ol igonucleotide in solution. The applicability of the method is demonstr ated by preparation of 3'-phosphorylated chimeric oligonucleotides con taining methyl phosphotriester and methyl phosphonate internucleosidic linkages. (C) 1997 Elsevier Science Ltd.