Expression of 5-HT2A and 5-HT1B receptor mRNA in blood vessels

Authors
Kato, S Kumamoto, H Hirano, M Akiyama, H Kaneko, N
Citation
S. Kato et al., Expression of 5-HT2A and 5-HT1B receptor mRNA in blood vessels, MOL C BIOCH, 199(1-2), 1999, pp. 57-61
Citations number
11
Categorie Soggetti
Cell & Developmental Biology
Journal title
MOLECULAR AND CELLULAR BIOCHEMISTRY
ISSN journal
03008177 → ACNP
Volume
199
Issue
1-2
Year of publication
1999
Pages
57 - 61
Database
ISI
SICI code
0300-8177(199909)199:1-2<57:EO5A5R>2.0.ZU;2-2
Abstract
Expression of two subtypes of 5-hydroxytryptamine (5-HT) receptors, 5-HT1B and 5-HT2A, was investigated in normal rat arteries (abdominal aorta) and v eins (inferior vena cava) by the quantitative reverse transcription-polymer ase chain reaction (RT-PCR). The arterial 5-HT2A receptor mRNA level in art ery was 25-fold (p < 0.01) higher than the venous level, and the arterial 5 -HT1B receptor mRNA level was at least 7000-fold (p < 0.005) higher the ven ous level.