Clinicopathological study of an autopsy case with sensory-dominant polyradiculoneuropathy with antiganglioside antibodies

A previously reported patient presenting sensory-dominant neuropathy with a ntiganglioside antibodies, bound preferentially to polysialogangliosides in cluding GD1b, was autopsied. While axonal degeneration was predominant in t he sural nerve, many demyelinated fibers were present in the spinal roots. Dorsal roots had undergone significant damage. These pathological findings were well correlated with the electrophysiological results showing decrease d F-wave conduction velocities and conduction blocks in motor nerves and de creased or absent sensory action potentials in sensory nerves, with distrib ution of GD1b in nerve tissues such as dorsal root ganglia and paranodal my elin in the ventral and dorsal roots. (C) 1999 John Wiley & Sons, Inc.