Bm. Li et al., Alpha-2 adrenergic modulation of prefrontal cortical neuronal activity related to spatial working memory in monkeys, NEUROPSYCH, 21(5), 1999, pp. 601-610
The effects of systemically administered or iontophoretically applied cloni
dine (alpha-2 adrenergic agonist) and iontophoretically applied yohimbine (
alpha-2 adrenergic antagonist) were examined on prefrontal cortical (PFC) n
eurons related to spatial working memory (SWM). Systemically administered c
lonidine (0.04 mg/kg) enhanced SWM-related PFC neuronal activity by 32.5 +/
- 14.5%, (mean +/- SD; n = 25 neurons). The facilitatory effect of clonidin
e was antagonized by iontophoretically applied yohimbine. Iontophoretically
applied clonidine enhanced SWM-related PFC neuronal activity by 38.2 +/- 1
8.6%, (n = 13 neurons), whereas similarly applied yohimbine suppressed it b
y 34.4 +/- 17.8% (n = 28 neurons). These results indicate that: a) systemic
ally administered clonidine can facilitate SWM-related PFC neuronal activit
y through actions at alpha-2 adrenoceptors In the PFC; and b) conversely, b
lockade by yohimbine of alpha-2 adrenoceptors in the PFC suppresses SWM-rel
ated neuronal activity. The present study provides neurophysiological evide
nce that alpha-2 adrenoceptors in the PFC are involved in the cellular mech
anisms underlying working memory. [Neuropsychopharmacology 21:601-610, 1999
] (C) 1999 American College of Neuropsychopharmacology. Published by Elsevi
er Science Inc.