D. Bartres-faz et al., Apo E influences declarative and procedural learning in age-associated memory impairment, NEUROREPORT, 10(14), 1999, pp. 2923-2927
AGE-ASSOCIATED memory impairment (AAMI) is a clinical entity which was orig
inally described to define memory problems linked to normal aging. Apolipop
rotein: E and ACE genes have both been associated With cognitive impairment
in aging and dementia, The purpose,of this study was to investigate memory
and executive functions in AAMI according to the genetic background. We fo
und that subjects carrying the Apo E epsilon 4 allele exhibit lower memory
performance on tests of both,declarative and procedural memory. We did not
find differences on frontal lobe tests. These findings give further support
to the hypothesis concerning a genetic susceptibility for cognitive impair
ment in aging. (C) 1999 Lippincott Williams & Wilkins.