Apo E influences declarative and procedural learning in age-associated memory impairment

Citation
D. Bartres-faz et al., Apo E influences declarative and procedural learning in age-associated memory impairment, NEUROREPORT, 10(14), 1999, pp. 2923-2927
Citations number
22
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROREPORT
ISSN journal
09594965 → ACNP
Volume
10
Issue
14
Year of publication
1999
Pages
2923 - 2927
Database
ISI
SICI code
0959-4965(19990929)10:14<2923:AEIDAP>2.0.ZU;2-D
Abstract
AGE-ASSOCIATED memory impairment (AAMI) is a clinical entity which was orig inally described to define memory problems linked to normal aging. Apolipop rotein: E and ACE genes have both been associated With cognitive impairment in aging and dementia, The purpose,of this study was to investigate memory and executive functions in AAMI according to the genetic background. We fo und that subjects carrying the Apo E epsilon 4 allele exhibit lower memory performance on tests of both,declarative and procedural memory. We did not find differences on frontal lobe tests. These findings give further support to the hypothesis concerning a genetic susceptibility for cognitive impair ment in aging. (C) 1999 Lippincott Williams & Wilkins.